Member of Adilkno, the Foundation for the Advancement of Illegal Knowledge, a free association of media-related intellectuals (Agentur Bilwet auf Deutsch). He is a radio program producer (for Radio Patapoe in Amsterdam and VPRO radio) and a co-founder of The Digital City, the Amsterdam-based Freenet and 'Press Now', the Dutch support campaign for independent media in Former Yugoslavia. Former editor of the media/art magazine Mediamatic (1989-1994). In 1991-1993 he lectured media theory in Bucharest and Budapest at the art academies there. Co-founder of the Amsterdam-based internet content providers desk.nl (culture/arts) and 'contrast.org' (politics) and a 'cultural ambassador' for Waag Society for Old and New Media. Regular contributor of Andere Sinema (Antwerpen) and member of the editorial board of ARKzin (Zagreb). In the spring of 1995, together with Pit Schultz, he founded the international nettime circle which is promoting 'net criticism'. In 2001 co-founded Fibreculture list.
Co-organized the Wetware Convention (Amsterdam, 1991), Next 5 Minutes, a international conference on public access and camcorder activism (Amsterdam, 1993), Ex Oriente Lux (Bucharest 1993), the first Romanian media/art event, MetaForum I/II/III (Budapest, 1994-6), Interface 3 (Hamburg, 1995) on the culture of computer networks, Next 5 Minutes II on 'tactical media' (Amsterdam, 1996). and moderated the (net) symposium of Ars Electronica 96 on 'memesis'. He was the project coordinator of the Hybrid WorkSpace, which took place during the Documenta X (1997) in Kassel. Later on co-organised Browser Day (Amsterdam, 1998-2002), Net.Congestion event (Amsterdam, 2000), and conferences such as Tulipomania DotCom (Amsterdam/Frankfurt, 2000), Dark Markets (Vienna, 2002), Networks, Art, & Collaboration (Buffalo, 2004), Incommunicado (Amsterdam, 2005), The Art and Politics of Netporn (Amsterdam, 2005), and New Network Theory (Amsterdam, 2007).
Among his publications are Adilkno's 'Empire of Images' (Amsterdam, 1985), 'Cracking the Movement' (Amsterdam, 1990/Berlin, 1991/New York, 1994) on the squatter movement in Amsterdam, 'Hoer zu oder Stirb' (Berlin, 1992) on free radio, 'Medien Archiv' (Amsterdam 1992/Mannheim 1993/New York 1997), 'Der Daten- dandy' (Amsterdam/Mannheim, 1994) and 'Elektronische Einsamkeit' (Köln, 1997)
In June 2004 founded Institute of Network Cultures in Amsterdam. In 2005-2006 he was a fellow at the Berlin Institute for Advanced Study (Wissenschaftskolleg zu Berlin), where he finished his third volume on critical Internet culture, Zero Comments (Routledge New York, 2007).
- Hör zu – oder stirb!, Edition ID – Archiv, Amsterdam and Berlin, 1992. (German)
- editor, with Diana McCarty, Pit Schultz and Vuk Cosic, The Beauty and the East, Ljubljana: Nettime (ZKP4), 1997.
- editor, with Pit Schultz (Nettime), Netzkritik: Materialien zur Internet-Debatte, trans. Bettina Seifried, Florian Rötzer and Thomas Atzert, Berlin: ID-Verlag, 1997, 220 pp.  (German)
- Dark Fiber, Tracking Critical Internet Culture, MIT Press, 2002, 394 pp. 
- Uncanny Networks, In Dialogues with the Virtual Intelligentsia, MIT Press, Cambridge, 2002. 
- My First Recession, Critical Internet Culture in Transition, V2-NAi, Rotterdam, 2003. 
- The Principle of Notworking, Concepts in Critical Internet Culture, Amsterdam University Press, 2005.
- editor, with Lipika Bansal and Paul Keller, In the Shade of the Commons. Towards a Culture of Open Networks, Amsterdam: Waag Society, 2006.
- editor, with Jodi Dean and Jon W. Anderson, Reformatting Politics: Information Technology and Global Civil Society, CRC Press, 2006, 237 pp.
- Zero Comments: Blogging and Critical Internet Culture, New York: Routledge, 2007, 312 pp.
- editor, with Ned Rossiter, MyCreativity Reader: A Critique of Creative Industries, Amsterdam: Institute of Network Cultures, 2007.
- editor, with Sabine Niederer, Video Vortex Reader: Responses to Youtube, Amsterdam: Institute of Network Cultures, 2008, 315 pp.
- with Pit Schultz, Jugendjahre der Netzkritik. Essays zu Web 1.0 (1995 – 1997), Amsterdam: Institute of Network Cultures, 2010, 96 pp. (German)
- editor, with Rachel Somers Miles, Video Vortex Reader II: Moving Images Beyond YouTube, Amsterdam: Institute of Network Cultures, 2011, 378 pp.
- editor, with Nathaniel Tkacz, Critical Point of View: A Wikpedia Reader, Amsterdam: Institute of Network Cultures, 2011.
- editor, with Miriam Rasch, Unlike Us Reader: Social Media Monopolies and Their Alternatives, Amsterdam: Institute of Network Cultures, 2013, 386 pp.
- editor, with Nathaniel Tkacz and Patricia de Vries, MoneyLab Reader: An Intervention in Digital Economy, Amsterdam: Institute of Network Cultures, 2015, 308 pp.
- with Ned Rossiter, Organization after Social Media, Minor Compositions, 2018, 182 pp. 
- with Andreas Broeckmann and David García, "The GHI of Tactical Media", Dec 2002.